FGF1ΔHBS ameliorates chronic kidney disease via PI3K/AKT mediated suppression of oxidative stress and inflammation

C57BL/6J mice after 3 weeks of chronic administration of rFGF1 WT (2？mg/kg body weight), rFGF1ΔHBS (2？mg/kg body weight), or control vehicle. a Representative images of PCNA or Ki-67 immunohistochemical staining of renal tissues (left panel) and quantitation using ImageJ software (right panel). Scale bar, 50？μm. b Expression of PCNA and Ki-67 in renal tissue as measured by western blot analyses (left panel) and quantitation using ImageJ software (right panel). Data are presented as the mean？±？SEM (n？=？6). *p？<？0.05, ***p？<？0.00