Ets-1 deficiency alleviates nonalcoholic steatohepatitis via weakening TGF-β1 signaling-mediated hepatocyte apoptosis

a, b Expression of Ets-1 was examined in biopsies from normal controls (n？=？5) and patients with NASH (n？=？12) ({"type":"entrez-geo","attrs":{"text":"GSE24807","term_id":"24807"}}GSE24807). a Some genes that changed significantly are listed. CXCL10, CXC motif chemokine ligand 10; SH3BP5, SH3 domain–binding protein 5; CYP2R1, cytochrome P450 2R1; FABP1, fatty acid-binding protein 1; TGFB1, transforming growth factor beta1. b The correlation between ETS-1 and TGFB1 was determined by using the linear regression test (P？<？0.01). c–e WT mice were fed with chow diet (n？=？5) and MCD diet (n？=？5) for 8 weeks and sacrificed. Hepatic mRNA levels of Tgfb1 (c) and Ets-1 (d) were examined using qRT-PCR. e Lysates of liver tissues were used for immunoblotting. Quantitative data represent mean？±？standard error of the mean (SEM). *P？<？0.05 and **P？<？0.0