%0 Journal Article
%T Ets-1 deficiency alleviates nonalcoholic steatohepatitis via weakening TGF-¦Â1 signaling-mediated hepatocyte apoptosis
%A Dechen Liu
%A Kai Li
%A Kai Wang
%A Peng Sun
%A Rufeng Xu
%A Xiao Han
%A Xiaoai Chang
%A Yunxia Zhu
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1672-4
%X a, b Expression of Ets-1 was examined in biopsies from normal controls (n£¿=£¿5) and patients with NASH (n£¿=£¿12) ({"type":"entrez-geo","attrs":{"text":"GSE24807","term_id":"24807"}}GSE24807). a Some genes that changed significantly are listed. CXCL10, CXC motif chemokine ligand 10; SH3BP5, SH3 domain¨Cbinding protein 5; CYP2R1, cytochrome P450 2R1; FABP1, fatty acid-binding protein 1; TGFB1, transforming growth factor beta1. b The correlation between ETS-1 and TGFB1 was determined by using the linear regression test (P£¿<£¿0.01). c¨Ce WT mice were fed with chow diet (n£¿=£¿5) and MCD diet (n£¿=£¿5) for 8 weeks and sacrificed. Hepatic mRNA levels of Tgfb1 (c) and Ets-1 (d) were examined using qRT-PCR. e Lysates of liver tissues were used for immunoblotting. Quantitative data represent mean£¿¡À£¿standard error of the mean (SEM). *P£¿<£¿0.05 and **P£¿<£¿0.0
%K Apoptosis
%K Mechanisms of disease
%K Non-alcoholic steatohepatitis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561928/