Targeting autophagy potentiates antitumor activity of Met-TKIs against Met-amplified gastric cancer

a, b Met-amplified GC cells were treated with Met-TKIs as indicated and lysates were immunoblotted for proteins. c MKN45 cells were treated with PHA-665752 (PHA) 200？nM or SU11274 (SU) 1？μM for 36？h and LC3-positive puncta were counted by confocal immunofluorescence (autophagosomes were green and 4′,6-diamidino-2-phenylindole (DAPI)-stained nuclei were blue). Scale bar, 5？μm. Data are expressed as median with interquartile range. *P？<？0.05 by nonparametric Mann–Whitney U-tes