LncRNA MIAT sponges miR-149-5p to inhibit efferocytosis in advanced atherosclerosis through CD47 upregulation

a Example of type III lesion in the internal carotid artery (extracellular lipid pool was detected by histology). On multicontrast-weighted MR images, iso-intensity on T1WI and slightly higher signal on T2WI (arrow), no enhancement in T1WI？+？. The asterisks (*) indicates lumen. JV indicates jugular vein. b Example of type IV–V lesion in the internal carotid artery (lipid-rich necrotic core was detected by histology). On multicontrast-weighted MR images, lipid-rich necrotic core (arrowheads) had slightly higher signal on both T1WI and T2WI and had enhancement in T1WI？+？(arrowheads). Lumen is severely stenosed. The asterisks (*) indicates lumen. c Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) analysis of expression of MIAT in the serum from control (Ctrl, n？=？20), asymptomatic (Asympt, n？=？18) or symptomatic (Sympt, n？=？20) subjects with recent TIA/stroke (*P<0.05, Asympt patients vs. Ctrl, #P<0.05, Sympt patients vs. Asympt patients). d, e Analysis of MIAT expression in the serum and aorta of atherosclerotic lesions of HFD-Fed ApoE？/？ mice and NCD-fed ApoE mice？/？ at 8 and 16 weeks by qRT-PCR (*P？<？0.05, HFD-fed ApoE？/？ mice vs. NCD-fed ApoE？/？ mice, #P<0.05, HFD-fed ApoE？/？ mice at 16 week vs. HFD-fed ApoE？/？ mice at 8 week, n？=？6/group