%0 Journal Article
%T LncRNA MIAT sponges miR-149-5p to inhibit efferocytosis in advanced atherosclerosis through CD47 upregulation
%A Bo Hu
%A Bo-wei Li
%A Chao Qin
%A Huijuan Jin
%A Ling Mao
%A Rui-ting Hu
%A Shao-li Chen
%A Shengcai Chen
%A Shuai Yang
%A Xue-ying Luo
%A Yanan Li
%A Yuan-peng Xia
%A Zi-ming Ye
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1409-4
%X a Example of type III lesion in the internal carotid artery (extracellular lipid pool was detected by histology). On multicontrast-weighted MR images, iso-intensity on T1WI and slightly higher signal on T2WI (arrow), no enhancement in T1WI£¿+£¿. The asterisks (*) indicates lumen. JV indicates jugular vein. b Example of type IV¨CV lesion in the internal carotid artery (lipid-rich necrotic core was detected by histology). On multicontrast-weighted MR images, lipid-rich necrotic core (arrowheads) had slightly higher signal on both T1WI and T2WI and had enhancement in T1WI£¿+£¿(arrowheads). Lumen is severely stenosed. The asterisks (*) indicates lumen. c Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) analysis of expression of MIAT in the serum from control (Ctrl, n£¿=£¿20), asymptomatic (Asympt, n£¿=£¿18) or symptomatic (Sympt, n£¿=£¿20) subjects with recent TIA/stroke (*P<0.05, Asympt patients vs. Ctrl, #P<0.05, Sympt patients vs. Asympt patients). d, e Analysis of MIAT expression in the serum and aorta of atherosclerotic lesions of HFD-Fed ApoE£¿/£¿ mice and NCD-fed ApoE mice£¿/£¿ at 8 and 16 weeks by qRT-PCR (*P£¿<£¿0.05, HFD-fed ApoE£¿/£¿ mice vs. NCD-fed ApoE£¿/£¿ mice, #P<0.05, HFD-fed ApoE£¿/£¿ mice at 16 week vs. HFD-fed ApoE£¿/£¿ mice at 8 week, n£¿=£¿6/group
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372637/