ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining “stemness”

Downregulation of GRP78 in pancreatic cancer cells affects metabolic pathways regulating survival Transcriptomic analysis was performed on shGRP78 versus control cells (a, b). a Volcano plot depicting the significantly deregulated genes (red？=？upregulated; green？=？downregulated). b Dot plot depicting the percentage of significantly deregulated genes by function. iTRAQ proteomic analysis was performed on shGRP78 versus control cells (c–f). c Heatmaps showing upregulated (red) and downregulated (green) genes. Deregulated genes were sorted according to (d) cellular component (e) molecular function, and (f) biological function. g Downregulation of GRP78 in shGRP78 was confirmed by western blottin