%0 Journal Article
%T ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining ¡°stemness¡±
%A Ashok Saluja
%A Brittany Durden
%A Nikita S. Sharma
%A Patricia Dauer
%A Roey Hadad
%A Santanu Banerjee
%A Sulagna Banerjee
%A Vikas Dudeja
%A Vineet K. Gupta
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1408-5
%X Downregulation of GRP78 in pancreatic cancer cells affects metabolic pathways regulating survival Transcriptomic analysis was performed on shGRP78 versus control cells (a, b). a Volcano plot depicting the significantly deregulated genes (red£¿=£¿upregulated; green£¿=£¿downregulated). b Dot plot depicting the percentage of significantly deregulated genes by function. iTRAQ proteomic analysis was performed on shGRP78 versus control cells (c¨Cf). c Heatmaps showing upregulated (red) and downregulated (green) genes. Deregulated genes were sorted according to (d) cellular component (e) molecular function, and (f) biological function. g Downregulation of GRP78 in shGRP78 was confirmed by western blottin
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372649/