Pharmacological stimulation of NQO1 decreases NADPH levels and ameliorates acute pancreatitis in mice

a, b Pancreas injury was estimated by hematoxylin and eosin staining and a histologic damage score. Cont, saline (0.9% NaCl)-treated control group; CAE, 50？μg/kg caerulein-only group; CAE？+？Dun 10, caerulein plus 10？mg/kg dunnione combined group; CAE？+？Dun 20, caerulein plus 20？mg/kg dunnione combined group; CAE？+？Dun 40, caerulein plus 40？mg/kg dunnione combined group; Dun, 40？mg/kg dunnione-only group. Scale bar: 200？μm. c The pancreas-to-bodyweight ratio and serum amylase/lipase levels were measured. Each value represents the mean？±？SD (n？=？5). *P？<？0.05, **P？<？0.0