Skewed Signaling through the Receptor for Advanced Glycation End-Products Alters the Proinflammatory Profile of Tumor-Associated Macrophages

Schematic representation of the two extreme phenotypes (M1 and M2) in the heterogeneity spectrum derived from macrophage polarization. M1 phenotype arises as a response to interferon-γ and LPS while M2 are generated in response to IL-4, IL-13, IL-10, immunocomplexes (IC), or glucocorticoids (GC). The classical M1 phenotype supports proinflammatry and tumoricidal responses. On the contrary M2 macrophages are supportive of anti-inflammatory and protumorigenic response