%0 Journal Article
%T Skewed Signaling through the Receptor for Advanced Glycation End-Products Alters the Proinflammatory Profile of Tumor-Associated Macrophages
%A Armando Rojas
%A Carolina A£¿azco
%A Fernando Delgado-L¨®pez
%A Ileana Gonzalez
%A Jacqueline Romero
%A Paulina Araya
%A Ramon Perez-Castro
%J Archive of "Cancer Microenvironment".
%D 2018
%R 10.1007/s12307-018-0214-4
%X Schematic representation of the two extreme phenotypes (M1 and M2) in the heterogeneity spectrum derived from macrophage polarization. M1 phenotype arises as a response to interferon-¦Ã and LPS while M2 are generated in response to IL-4, IL-13, IL-10, immunocomplexes (IC), or glucocorticoids (GC). The classical M1 phenotype supports proinflammatry and tumoricidal responses. On the contrary M2 macrophages are supportive of anti-inflammatory and protumorigenic response
%K Receptor for advanced glycation end-products
%K Tumor microenvironment
%K Macrophage polarization
%K Alarmins
%K Tumor-associated macrophages
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250617/