LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma

a mRNA levels for LXRα were obtained from TCGA_KIRC datasets and Oncomine datasets (Gumz Renal, Jones Renal, Yusenko Renal, Lenburg Renal, and Beroukhim Renal). b mRNA levels of LXRα compared with different clinicopathological features: T stage, G stage and TNM stage. c The OS of ccRCC patients is correlated with expression of LXRα, and high expression of LXRα indicates a poor prognosis in T0 and G1+G2 stage ccRCC patients. d Expression of LXRα differentiates the adjacent normal tissues and ccRCC cancer tissues according to the ROC curve analysis. ROC curve analysis of LXRα expression in subgroups of ccRCC patients with (T1+T2) VS (T3+T4) stage and (G1+G2) VS (G3+G4) stage was also performed. e Western blotting and qRT-PCR analysis of LXRα protein and mRNA expression levels in ccRCC cell lines and HK-2 cells. f Expression levels of LXRα protein and mRNA in ccRCC cancer tissue and normal kidney tissue. g Immunohistochemistry (IHC) analysis of LXRα expression in ccRCC tissues and normal kidney tissues. Original magnification x200 (Data are shown as mean？±？SD. ****P？<？0.0001; ***P？<？0.001; **P？<？0.01; *P？<？0.05, and ns means no significant difference compared with the corresponding control