%0 Journal Article
%T LXR¦Á promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma
%A Cheng Wang
%A Di Liu
%A Gong Cheng
%A HaiBing Xiao
%A HaiLong Ruan
%A HongMei Yang
%A HuaGeng Liang
%A Jingchong Liu
%A Ke Chen
%A KeShan Wang
%A Lin Bao
%A Qi Cao
%A TianBo Xu
%A XiaoPing Zhang
%A ZhaoHui Chen
%A ZhengShuai Song
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1345-3
%X a mRNA levels for LXR¦Á were obtained from TCGA_KIRC datasets and Oncomine datasets (Gumz Renal, Jones Renal, Yusenko Renal, Lenburg Renal, and Beroukhim Renal). b mRNA levels of LXR¦Á compared with different clinicopathological features: T stage, G stage and TNM stage. c The OS of ccRCC patients is correlated with expression of LXR¦Á, and high expression of LXR¦Á indicates a poor prognosis in T0 and G1+G2 stage ccRCC patients. d Expression of LXR¦Á differentiates the adjacent normal tissues and ccRCC cancer tissues according to the ROC curve analysis. ROC curve analysis of LXR¦Á expression in subgroups of ccRCC patients with (T1+T2) VS (T3+T4) stage and (G1+G2) VS (G3+G4) stage was also performed. e Western blotting and qRT-PCR analysis of LXR¦Á protein and mRNA expression levels in ccRCC cell lines and HK-2 cells. f Expression levels of LXR¦Á protein and mRNA in ccRCC cancer tissue and normal kidney tissue. g Immunohistochemistry (IHC) analysis of LXR¦Á expression in ccRCC tissues and normal kidney tissues. Original magnification x200 (Data are shown as mean£¿¡À£¿SD. ****P£¿<£¿0.0001; ***P£¿<£¿0.001; **P£¿<£¿0.01; *P£¿<£¿0.05, and ns means no significant difference compared with the corresponding control
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377709/