DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis

a MAVER-1, b K562, c H929 and d H1299 cells were exposed to Z-VAD.fmk (30？μM) for 0.5？h, followed by ABT-199 (100？nM), A-1331852 (100？nM), A-1210477 (10？μM), or a combination of A-1331852 (100？nM) and A-1210477 (10？μM), respectively, for 4？h and assessed for mitochondrial structural changes by electron microscopy. Yellow arrowheads indicate regions of breaks at the outer mitochondrial membrane. Scale bars: 500？n