%0 Journal Article
%T DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis
%A Alison J. Beckett
%A Aoula Al-Zebeeby
%A Gerald M. Cohen
%A Ian A. Prior
%A Mateus Milani
%A Shankar Varadarajan
%A Xu Luo
%J Archive of "Cell Death Discovery".
%D 2019
%R 10.1038/s41420-019-0199-x
%X a MAVER-1, b K562, c H929 and d H1299 cells were exposed to Z-VAD.fmk (30£¿¦ÌM) for 0.5£¿h, followed by ABT-199 (100£¿nM), A-1331852 (100£¿nM), A-1210477 (10£¿¦ÌM), or a combination of A-1331852 (100£¿nM) and A-1210477 (10£¿¦ÌM), respectively, for 4£¿h and assessed for mitochondrial structural changes by electron microscopy. Yellow arrowheads indicate regions of breaks at the outer mitochondrial membrane. Scale bars: 500£¿n
%K Cell death
%K Organelles
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637195/