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-  2019 

Pristimerin induces apoptosis and autophagy via activation of ROS/ASK1/JNK pathway in human breast cancer in vitro and in vivo

DOI: 10.1038/s41420-019-0208-0

Keywords: Breast cancer, Pharmacology

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Abstract:

a MDA-MB-231 and MDA-MB-468 cells were treated with various concentrations of pristimerin for 24, 48, and 72?h. Cell viability was analyzed by MTT assay. b The effect of pristimerin on normal human breast epithelial cells of the MCF-10A line is shown. c The results from the colony formation assay of MDA-MB-231 and MDA-MB-468 cells after pristimerin treatment are shown. d MDA-MB-231 and MDA-MB-468 cells were treated with pristimerin for 24?h, and the cell cycle distribution percentages were analyzed by flow cytometry. e The cells were treated with various concentrations of pristimerin for 24?h, and the expression of cell cycle-regulated proteins was detected by Western blotting. Results from three independent experiments are presented. *P?<?0.05, **P?<?0.01 and ***P?<?0.001 versus control, #P?<?0.05, ##P?<?0.01 and ###P?<?0.001 versus pristimerin treatmen

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