%0 Journal Article
%T Pristimerin induces apoptosis and autophagy via activation of ROS/ASK1/JNK pathway in human breast cancer in vitro and in vivo
%A Jing Zhong
%A Junjun Jia
%A Mengting Yu
%A Qun Zhao
%A Xiang Li
%A Xianjun Yu
%A Yingxiang Liu
%A Yongqiang Liu
%A Yun Bi
%A Ziting Ren
%J Archive of "Cell Death Discovery".
%D 2019
%R 10.1038/s41420-019-0208-0
%X a MDA-MB-231 and MDA-MB-468 cells were treated with various concentrations of pristimerin for 24, 48, and 72£¿h. Cell viability was analyzed by MTT assay. b The effect of pristimerin on normal human breast epithelial cells of the MCF-10A line is shown. c The results from the colony formation assay of MDA-MB-231 and MDA-MB-468 cells after pristimerin treatment are shown. d MDA-MB-231 and MDA-MB-468 cells were treated with pristimerin for 24£¿h, and the cell cycle distribution percentages were analyzed by flow cytometry. e The cells were treated with various concentrations of pristimerin for 24£¿h, and the expression of cell cycle-regulated proteins was detected by Western blotting. Results from three independent experiments are presented. *P£¿<£¿0.05, **P£¿<£¿0.01 and ***P£¿<£¿0.001 versus control, #P£¿<£¿0.05, ##P£¿<£¿0.01 and ###P£¿<£¿0.001 versus pristimerin treatmen
%K Breast cancer
%K Pharmacology
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680048/