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-  2019 

Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma

DOI: 10.1038/s41420-019-0194-2

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Abstract:

a αB-Crystallin (red) was detected in the nerve fiber layer (NFL) and in the outer plexiform layer (OPL) in the non-glaucomatous retinas. Only very weak immunostaining in the NFL was observed in the glaucomatous retinas. Representative images from the human retinas. The RGCs were labeled with a Brn3a antibody (green). The cell nuclei were stained with DAPI (blue). Scale bar?=?50?μm. b The number of RGCs in the retinas of the CRYAB KO mice was lower than that in the retinas of the age-matched WT mice. The bar graphs represent the means?±?SD of triplicate measurements. Scale bar?=?200?μm. ns not significant, *p?<?0.05 (unpaired t-test). GLC?=?ganglion cell laye

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