%0 Journal Article
%T Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma
%A Dorota L. Stankowska
%A Mi-Hyun Nam
%A Rafal Fudala
%A Raghu R. Krishnamoorthy
%A Ram H. Nagaraj
%A Renuka M. Chaphalkar
%A Rooban B. Nahomi
%A Sandip K. Nandi
%J Archive of "Cell Death Discovery".
%D 2019
%R 10.1038/s41420-019-0194-2
%X a ¦ÁB-Crystallin (red) was detected in the nerve fiber layer (NFL) and in the outer plexiform layer (OPL) in the non-glaucomatous retinas. Only very weak immunostaining in the NFL was observed in the glaucomatous retinas. Representative images from the human retinas. The RGCs were labeled with a Brn3a antibody (green). The cell nuclei were stained with DAPI (blue). Scale bar£¿=£¿50£¿¦Ìm. b The number of RGCs in the retinas of the CRYAB KO mice was lower than that in the retinas of the age-matched WT mice. The bar graphs represent the means£¿¡À£¿SD of triplicate measurements. Scale bar£¿=£¿200£¿¦Ìm. ns not significant, *p£¿<£¿0.05 (unpaired t-test). GLC£¿=£¿ganglion cell laye
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609721/