Letter to the Editor Re: Ogawa, Y. Cancers 2016, 8, 28

We read with interest the recently published paper by Dr. Ogawa “Paradigm Shift in Radiation Biology/Radiation Oncology—Exploitation of the H2O2 Effect” for Radiotherapy Using Low-LET (Linear Energy Transfer) Radiation such as X-rays and High-Energy Electrons”. This paper suggests the use of hydrogen peroxide to convert the phenotype of solid tumors from radiation-resistant to radiation-sensitive. This novel approach could have wide application if the distribution of peroxide could be made sufficiently uniform to re-oxygenate cells that were resistant due to hypoxia and Dr. Ogawa additionally suggests that inactivation of peroxidases (e.g., glutathione peroxidase and catalase) by the hydrogen peroxide will itself cause sensitization [1]