%0 Journal Article
%T Letter to the Editor Re: Ogawa, Y. Cancers 2016, 8, 28
%A Cameron J. Koch
%J Archive of "Cancers".
%D 2016
%R 10.3390/cancers8060053
%X We read with interest the recently published paper by Dr. Ogawa ¡°Paradigm Shift in Radiation Biology/Radiation Oncology¡ªExploitation of the H2O2 Effect¡± for Radiotherapy Using Low-LET (Linear Energy Transfer) Radiation such as X-rays and High-Energy Electrons¡±. This paper suggests the use of hydrogen peroxide to convert the phenotype of solid tumors from radiation-resistant to radiation-sensitive. This novel approach could have wide application if the distribution of peroxide could be made sufficiently uniform to re-oxygenate cells that were resistant due to hypoxia and Dr. Ogawa additionally suggests that inactivation of peroxidases (e.g., glutathione peroxidase and catalase) by the hydrogen peroxide will itself cause sensitization [1]
%K IR direct effect
%K IR indirect effect
%K oxygen effect
%K radiation sensitizers
%K radiation protectors
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931618/