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-  2019 

Low-dose 2-deoxyglucose and metformin synergically inhibit proliferation of human polycystic kidney cells by modulating glucose metabolism

DOI: 10.1038/s41420-019-0156-8

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a WT9-7 cells were treated with 2-DG (0.6, 2.5, 10 and 40?mM) for 12, 24, 36 and 48?h, and the cell viability was determined using CCK-8 assay. b WT9-7 cells were treated with MET (0.6, 2.5, 10 and 40?mM) for 12, 24, 36 and 48?h, and the cell viability was determined using CCK-8 assay. c Cells were treated with various concentrations (0.6, 2.5, 10 and 40?mM) of 2-DG or MET for 48?h, and the half- maximal inhibitory concentration (IC50) was determined using GraphPad Prism software. d The combined treatment with 2-DG and MET enhanced the growth inhibition of WT9-7 cells. WT9-7 cells were treated with 2-DG and MET at different doses (1.3?+?0.6, 2.5?+?1.3, 5?+?2.5 and 10?+?5?mM) for 12, 24, 36 and 48?h, and the cell viability was determined using the CCK-8 assay. e HRPTEC cells were treated with 2-DG (5?mM), MET (2.5?mM) and their combination for 48?h, and the cell viability was determined using CCK-8 assay; *p?<?0.05, **p?<?0.01, ***p?<?0.001 vs Contro

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