%0 Journal Article
%T Low-dose 2-deoxyglucose and metformin synergically inhibit proliferation of human polycystic kidney cells by modulating glucose metabolism
%A Bo Fu
%A Guangyan Cai
%A Jing Zhao
%A Qinggang Li
%A Xiangmei Chen
%A Xiaoyuan Wu
%A Xue-Yuan Bai
%A Yingjie Zhang
%A Yuxiang Ma
%J Archive of "Cell Death Discovery".
%D 2019
%R 10.1038/s41420-019-0156-8
%X a WT9-7 cells were treated with 2-DG (0.6, 2.5, 10 and 40£¿mM) for 12, 24, 36 and 48£¿h, and the cell viability was determined using CCK-8 assay. b WT9-7 cells were treated with MET (0.6, 2.5, 10 and 40£¿mM) for 12, 24, 36 and 48£¿h, and the cell viability was determined using CCK-8 assay. c Cells were treated with various concentrations (0.6, 2.5, 10 and 40£¿mM) of 2-DG or MET for 48£¿h, and the half- maximal inhibitory concentration (IC50) was determined using GraphPad Prism software. d The combined treatment with 2-DG and MET enhanced the growth inhibition of WT9-7 cells. WT9-7 cells were treated with 2-DG and MET at different doses (1.3£¿+£¿0.6, 2.5£¿+£¿1.3, 5£¿+£¿2.5 and 10£¿+£¿5£¿mM) for 12, 24, 36 and 48£¿h, and the cell viability was determined using the CCK-8 assay. e HRPTEC cells were treated with 2-DG (5£¿mM), MET (2.5£¿mM) and their combination for 48£¿h, and the cell viability was determined using CCK-8 assay; *p£¿<£¿0.05, **p£¿<£¿0.01, ***p£¿<£¿0.001 vs Contro
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411866/