miR-340-FHL2 axis inhibits cell growth and metastasis in ovarian cancer

a Dysregulated miRNAs in OC compared with the corresponding control in both {"type":"entrez-geo","attrs":{"text":"GSE71477","term_id":"71477"}}GSE71477 and {"type":"entrez-geo","attrs":{"text":"GSE47841","term_id":"47841"}}GSE47841 datasets, in which 15 are downregulated and 21 are upregulated (P？<？0.025, fold change <0.8 or >1.25). b Heatmap showing the hierarchical clustering of miRNAs expressed in human OC from {"type":"entrez-geo","attrs":{"text":"GSE71477","term_id":"71477"}}GSE71477 dataset. c Expression of miR-340 was significantly downregulated in OC compared with that of ovarian epithelium ({"type":"entrez-geo","attrs":{"text":"GSE47841","term_id":"47841"}}GSE47841) or endometrium ({"type":"entrez-geo","attrs":{"text":"GSE71477","term_id":"71477"}}GSE71477). Data are shown as means？±？SEM. d, e A2780 and SKOV3 cells were treated with 5-aza-2′-deoxycytidine (5-Aza-dC) (d) for 48？h or trichostatin A (TSA) (e) for 24？h. The relative expression of miR-340 was determined by real-time RT-PCR. Data are shown as means？±？SD from three independent experiments. *P？<？0.05, **P？<？0.01 by Student’s t-test