%0 Journal Article
%T miR-340-FHL2 axis inhibits cell growth and metastasis in ovarian cancer
%A Jian-an Zhang
%A Jianmin Wu
%A Jingwen Geng
%A Kaili Luo
%A Liying Ji
%A Mengyao Qian
%A Qinkai Zhang
%A Qiuxia Li
%A Xunzhu Zhou
%A Yesha Xu
%A Zheng Huang
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1604-3
%X a Dysregulated miRNAs in OC compared with the corresponding control in both {"type":"entrez-geo","attrs":{"text":"GSE71477","term_id":"71477"}}GSE71477 and {"type":"entrez-geo","attrs":{"text":"GSE47841","term_id":"47841"}}GSE47841 datasets, in which 15 are downregulated and 21 are upregulated (P£¿<£¿0.025, fold change <0.8 or >1.25). b Heatmap showing the hierarchical clustering of miRNAs expressed in human OC from {"type":"entrez-geo","attrs":{"text":"GSE71477","term_id":"71477"}}GSE71477 dataset. c Expression of miR-340 was significantly downregulated in OC compared with that of ovarian epithelium ({"type":"entrez-geo","attrs":{"text":"GSE47841","term_id":"47841"}}GSE47841) or endometrium ({"type":"entrez-geo","attrs":{"text":"GSE71477","term_id":"71477"}}GSE71477). Data are shown as means£¿¡À£¿SEM. d, e A2780 and SKOV3 cells were treated with 5-aza-2¡ä-deoxycytidine (5-Aza-dC) (d) for 48£¿h or trichostatin A (TSA) (e) for 24£¿h. The relative expression of miR-340 was determined by real-time RT-PCR. Data are shown as means£¿¡À£¿SD from three independent experiments. *P£¿<£¿0.05, **P£¿<£¿0.01 by Student¡¯s t-test
%K Cancer
%K Translational research
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506554/