Decreased IL-17RB expression impairs CD11b+CD11c？ myeloid cell accumulation in gastric mucosa and host defense during the early-phase of Helicobacter pylori infection

a IL-17RB mRNA expression in gastric mucosa of H. pylori-infected (n？=？80) and uninfected donors (n？=？16) were compared. b The correlation between IL-17RB mRNA expression and H. pylori colonization in gastric mucosa of H. pylori-infected donors was analyzed. c IL-17RB mRNA expression in gastric mucosa of uninfected (n？=？16), cagA+ H. pylori-infected (n？=？67), cagA？ and H. pylori-infected (n？=？13) donors was compared. d Dynamic changes of IL-17RB mRNA expression and IL-17RB mRNA expression on day 7 or 9 p.i. in gastric mucosa of WT H. pylori-infected, ΔcagA-infected, and uninfected mice. n？=？5 per group per time point in (d). e IL-17RB protein in gastric mucosa of WT H. pylori-infected, ΔcagA-infected, and uninfected mice on day 9 p.i. were analyzed by IHC. Scale bars: 100？μm. f IL-17RB protein in gastric mucosa of WT H. pylori-infected, ΔcagA-infected, and uninfected mice on day 9 p.i. were analyzed by Western blot. g IL-17RB mRNA expression or IL-17RB protein in WT H. pylori-infected, ΔcagA-infected, and uninfected isolated primary gastric mucosa tissues (MOI？=？100, 24？h) from uninfected donors were compared (n？=？3) analyzed by real time PCR or Western blot. *P？<？0.05, ** P？<？0.01, n.s P？>？0.05 for groups connected by horizontal lines compared, or compared with uninfected mic