SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals

Cells with overexpressed SCD1 were resistant to Gefitinib. a, b The expression of SCD1 in five lung cancer cell lines A549, H838, H1573 and one normal human bronchial epithelial cells BEAS-2B was analyzed. c, d The cell vitality of A549 and H1573 with or without SCD1 overexpression was assessed after treatment with different doses of Gefitinib (0, 5, 10, 20, 40, and 80 μM) for 72 h. NC negative control.***p？<？0.001, data is presented as mean？±？s