%0 Journal Article
%T SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals
%A Hui Pan
%A Jiaxi He
%A Jun Huang
%A Kelin She
%A Liyan Huang
%A Ping He
%A Shenghua Fang
%A Wei Du
%A Xingxing Fan
%J Archive of "Cancer Cell International".
%D 2019
%R 10.1186/s12935-019-0809-y
%X Cells with overexpressed SCD1 were resistant to Gefitinib. a, b The expression of SCD1 in five lung cancer cell lines A549, H838, H1573 and one normal human bronchial epithelial cells BEAS-2B was analyzed. c, d The cell vitality of A549 and H1573 with or without SCD1 overexpression was assessed after treatment with different doses of Gefitinib (0, 5, 10, 20, 40, and 80 ¦ÌM) for 72 h. NC negative control.***p£¿<£¿0.001, data is presented as mean£¿¡À£¿s
%K SCD1
%K EGFR
%K AKT
%K EMT
%K Lung cancer
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472070/