SR 11302, an AP-1 Inhibitor, Reduces Metastatic Lesion Formation in Ex Vivo 4D Lung Cancer Model

Relative gene expression (2-ΔΔCt) of c-Jun and c-Fos genes in primary tumors (PTs), circulatory tumor cells (CTCs), and metastatic lesions (MLs) from a 4D ex vivo lung model seeded with A549 (a & d), H1299 (b & e), and H460 (C & F), cells. a, b, & c c-Jun was significantly upregulated in CTCs as compared to respective PTs for all three-cell lines. d, e & f: c-Fos was significantly upregulated in CTCs as compared to respective PTs and metastatic lesions in all three-cell line