Long noncoding RNA PXN-AS1-L promotes non-small cell lung cancer progression via regulating PXN

PXN-AS1-L was up-regulated in NSCLC and associated with poor prognosis. a The expressions of PXN-AS1-L in normal bronchial epithelial cell line 16HBE and NSCLC cell lines NCI-H1975, A549, NCI-H1299, and SK-MES-1 were detected by qPCR. Results are shown as mean？±？SD of three independent experiments. ***P？<？0.001 by Student’s t-test. b The expressions of PXN-AS1-L in 66 pairs of NSCLC tissues and adjacent noncancerous lung tissues were detected by qPCR. P？<？0.0001 by Wilcoxon signed-rank test. c The expressions of PXN-AS1-L in 66 primary NSCLC tissues and 10 NSCLC bone metastases tissues were detected by qPCR. P？<？0.0001 by Mann–Whitney test. d Kaplan–Meier survival analysis of the correlation between PXN-AS1-L expression and overall survival of these 66 NSCLC patients. The median PXN-AS1-L expression level was used as the cut-off. P？<？0.0001 by Log-rank tes