%0 Journal Article
%T Long noncoding RNA PXN-AS1-L promotes non-small cell lung cancer progression via regulating PXN
%A Jiaqi Wang
%A Junying Cao
%A Kai Song
%A Wei Hu
%A Xuesong Zhang
%A Yan Wang
%A Yongyu Hao
%A Zhaohui Peng
%A Zhifa Zhang
%J Archive of "Cancer Cell International".
%D 2019
%R 10.1186/s12935-019-0734-0
%X PXN-AS1-L was up-regulated in NSCLC and associated with poor prognosis. a The expressions of PXN-AS1-L in normal bronchial epithelial cell line 16HBE and NSCLC cell lines NCI-H1975, A549, NCI-H1299, and SK-MES-1 were detected by qPCR. Results are shown as mean£¿¡À£¿SD of three independent experiments. ***P£¿<£¿0.001 by Student¡¯s t-test. b The expressions of PXN-AS1-L in 66 pairs of NSCLC tissues and adjacent noncancerous lung tissues were detected by qPCR. P£¿<£¿0.0001 by Wilcoxon signed-rank test. c The expressions of PXN-AS1-L in 66 primary NSCLC tissues and 10 NSCLC bone metastases tissues were detected by qPCR. P£¿<£¿0.0001 by Mann¨CWhitney test. d Kaplan¨CMeier survival analysis of the correlation between PXN-AS1-L expression and overall survival of these 66 NSCLC patients. The median PXN-AS1-L expression level was used as the cut-off. P£¿<£¿0.0001 by Log-rank tes
%K Long noncoding RNA
%K Non-small-cell lung cancer
%K Proliferation
%K Migration
%K PXN
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341638/