OALib Journal期刊
ISSN: 2333-9721
费用:99美元
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Discovery of GBT440,
an Orally Bioavailable R-State
Stabilizer of Sickle Cell Hemoglobin
DOI: 10.1021/acsmedchemlett.6b00491
Abel Silva-Garcia, Athiwat Hutchaleelaha, Bradley P. Morgan, Brian Metcalf, Calvin Yee, Carl Johnson, Chihyuan Chuang, Donghong Xu, Donna Oksenberg, James R. Partridge, Jason Harris, Joyce James, Kobina Dufu, Kumar Paulvannan, Lan Hua, Larysa Patskovska, Matthew P. Jacobson, Mira P. Patel, Qing Lu, Qing Xu, Stephen L. Gwaltney, II, Steven C. Almo, Zhe Li
Keywords: Sickle cell disease, sickle cell hemoglobin, allosteric modulator, aldehyde, Schiff-base formation, oxygen affinity, red blood cell partitioning
Abstract:
Full-Text
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