%0 Journal Article
%T Discovery of GBT440,
an Orally Bioavailable R-State
Stabilizer of Sickle Cell Hemoglobin
%A Abel Silva-Garcia
%A Athiwat Hutchaleelaha
%A Bradley P. Morgan
%A Brian Metcalf
%A Calvin Yee
%A Carl Johnson
%A Chihyuan Chuang
%A Donghong Xu
%A Donna Oksenberg
%A James R. Partridge
%A Jason Harris
%A Joyce James
%A Kobina Dufu
%A Kumar Paulvannan
%A Lan Hua
%A Larysa Patskovska
%A Matthew P. Jacobson
%A Mira P. Patel
%A Qing Lu
%A Qing Xu
%A Stephen L. Gwaltney
%A II
%A Steven C. Almo
%A Zhe Li
%J Archive of "ACS Medicinal Chemistry Letters".
%D 2017
%R 10.1021/acsmedchemlett.6b00491
%K Sickle cell disease
%K sickle cell hemoglobin
%K allosteric modulator
%K aldehyde
%K Schiff-base formation
%K oxygen affinity
%K red blood cell partitioning
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346980/