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OALib Journal期刊
ISSN: 2333-9721
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-  2017 

Zfra restores memory deficits in Alzheimer's disease triple-transgenic mice by blocking aggregation of TRAPPC6AΔ, SH3GLB2, tau, and amyloid β, and inflammatory NF-κB activation

DOI: 10.1016/j.trci.2017.02.001

Keywords: Zfra, TRAPPC6A, SH3GLB2, WWOX, Peptide polymerization, Protein degradation, Neurodegeneration

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Abstract:

Zinc finger-like protein that regulates apoptosis (Zfra) is a naturally occurring 31-amino-acid protein. Synthetic peptides Zfra1–31 and Zfra4–10 are known to effectively block the growth of many types of cancer cells

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