NGP 555, a γ-secretase modulator, lowers the amyloid biomarker, Aβ42, in cerebrospinal fluid while preventing Alzheimer's disease cognitive decline in rodents

DOI: 10.1016/j.trci.2016.09.003

Keywords: Alzheimer's, Amyloid, Modulator, Biomarkers, Pathology, Prevention, Cognition, Cerebrospinal fluid, Dementia, Gamma-secretase

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Abstract:

Alzheimer's disease (AD) is defined by the progressive accumulation of amyloid plaques and neurofibrillary tangles in the brain which precedes cognitive decline by years

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