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- 2019
Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD miceDOI: 10.1016/j.trci.2019.01.003 Keywords: Sleep-wake cycles, Sleep fragmentation, Orexin, Dual orexin receptor antagonist, Amyloid β, Neuroinflammation, Alzheimer's disease Abstract: Sleep disruption is a characteristic of Alzheimer's disease (AD) that may exacerbate disease progression. This study tested whether a dual orexin receptor antagonist (DORA) would enhance sleep and attenuate neuropathology, neuroinflammation, and cognitive deficits in an AD-relevant mouse model, 5XFAD
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