%0 Journal Article
%T Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice
%A Adam D. Bachstetter
%A Bruce F. O'Hara
%A Chairtra Tirumalaraju
%A Chanung Wang
%A Do-Hyun Yun
%A Hannah Farlow
%A James A. Howard
%A Kristen J. McQuerry
%A Madison N. Sanden
%J Archive of "Alzheimer's & Dementia : Translational Research & Clinical Interventions".
%D 2019
%R 10.1016/j.trci.2019.01.003
%X Sleep disruption is a characteristic of Alzheimer's disease (AD) that may exacerbate disease progression. This study tested whether a dual orexin receptor antagonist (DORA) would enhance sleep and attenuate neuropathology, neuroinflammation, and cognitive deficits in an AD-relevant mouse model, 5XFAD
%K Sleep-wake cycles
%K Sleep fragmentation
%K Orexin
%K Dual orexin receptor antagonist
%K Amyloid ¦Â
%K Neuroinflammation
%K Alzheimer's disease
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396100/