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OALib Journal期刊
ISSN: 2333-9721
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-  2019 

EXPRESSION OF IMMUNOGLOBULIN, GRANZYME-B AND PERFORIN AGAINST Ag85A AND Ag85B PROTEINS OF MYCOBACTERIUM TUBERCULOSIS IN BALB/C MICE

DOI: 10.21010/ajid.v13i2.2

Keywords: Ag85A and Ag85B proteins, Immunoglobulin, granzyme B and perforin, TB Vaccine

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Abstract:

Ag85 is a protein that may maintain survival of M. tuberculosis in intracellular parts of host cells and is considered as a virulence factor. The expression of Ag85 protein can stimulate proliferation and differentiation of B- cells and T-cells in patients with tuberculosis. This research aimed to determine the ability of Ag85A and Ag85B proteins in activating the response of antibodies, granzyme-B and perforin in Balb/c mice

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