In This Issue, Volume 7, Issue 7

Antifolates have been developed for treatment of a variety of diseases, including both infectious diseases and various malignancies, but these negatively charged compounds are poor antibacterial agents owing to a lack of cell permeability. Hybrid zwitterionic compounds have been designed and synthesized that are highly potent against both the enzyme and Gram-positive bacteria and show promising potency against Gram-negative bacteri