%0 Journal Article
%T In This Issue, Volume 7, Issue 7
%A Kristen
N. Kindrachuk
%J Archive of "ACS Medicinal Chemistry Letters".
%D 2016
%R 10.1021/acsmedchemlett.6b00260
%X Antifolates have been developed for treatment of a variety of diseases, including both infectious diseases and various malignancies, but these negatively charged compounds are poor antibacterial agents owing to a lack of cell permeability. Hybrid zwitterionic compounds have been designed and synthesized that are highly potent against both the enzyme and Gram-positive bacteria and show promising potency against Gram-negative bacteri
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947997/