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-  2018 

Coordinate systems for supergenomes

DOI: 10.1186/s13015-018-0133-4

Keywords: Comparative genomics, Comparative transcriptomics, Big data, Graph theory, Betweenness ordering, Colored multigraph, Combinatorial optimization

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Abstract:

Genome sequences and genome annotation data have become available at ever increasing rates in response to the rapid progress in sequencing technologies. As a consequence the demand for methods supporting comparative, evolutionary analysis is also growing. In particular, efficient tools to visualize-omics data simultaneously for multiple species are sorely lacking. A first and crucial step in this direction is the construction of a common coordinate system. Since genomes not only differ by rearrangements but also by large insertions, deletions, and duplications, the use of a single reference genome is insufficient, in particular when the number of species becomes large

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