%0 Journal Article
%T Coordinate systems for supergenomes
%A Christian H£¿ner zu Siederdissen
%A Fabian G£¿rtner
%A Lydia M¨¹ller
%J Archive of "Algorithms for Molecular Biology : AMB".
%D 2018
%R 10.1186/s13015-018-0133-4
%X Genome sequences and genome annotation data have become available at ever increasing rates in response to the rapid progress in sequencing technologies. As a consequence the demand for methods supporting comparative, evolutionary analysis is also growing. In particular, efficient tools to visualize-omics data simultaneously for multiple species are sorely lacking. A first and crucial step in this direction is the construction of a common coordinate system. Since genomes not only differ by rearrangements but also by large insertions, deletions, and duplications, the use of a single reference genome is insufficient, in particular when the number of species becomes large
%K Comparative genomics
%K Comparative transcriptomics
%K Big data
%K Graph theory
%K Betweenness ordering
%K Colored multigraph
%K Combinatorial optimization
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151955/