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- 2019
Altered expression of insulin-degrading enzyme and regulator of calcineurin in the rat intracerebral streptozotocin model and human apolipoprotein E-ε4–associated Alzheimer's diseaseDOI: 10.1016/j.dadm.2019.03.004 Keywords: Alzheimer's disease, Insulin deficiency, Insulin resistance, Streptozotocin, Insulin-degrading enzyme, RCAN1, Neurodegeneration Abstract: This study assesses insulin-degrading enzyme (IDE) and regulator of calcineurin 1 (RCAN1) as potential mediators of brain insulin deficiency and neurodegeneration in experimental and human Alzheimer's disease (AD)
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