Response to Sandford et？al.: PRICKLE2 Variants in Epilepsy: A Call for Precision Medicine

To the Editor: With the arrival of massively parallel sequencing (MPS), we now face the situation where we often discover several rare mutations in a single individual. So, how do we know which genes are associated with which phenotypes? Although this issue is common in 2016, it was not always the case. In the not-so-distant past, gene sequencing itself was a laborious process, and many genetic studies necessarily took a candidate-gene approach. The letter from Sandford et al. struggles with this recent history.