%0 Journal Article %T Response to Sandford et£¿al.: PRICKLE2 Variants in Epilepsy: A Call for Precision Medicine %A Vinit£¿B. Mahajan %J Archive of "American Journal of Human Genetics". %D 2016 %R 10.1016/j.ajhg.2016.02.002 %X To the Editor: With the arrival of massively parallel sequencing (MPS), we now face the situation where we often discover several rare mutations in a single individual. So, how do we know which genes are associated with which phenotypes? Although this issue is common in 2016, it was not always the case. In the not-so-distant past, gene sequencing itself was a laborious process, and many genetic studies necessarily took a candidate-gene approach. The letter from Sandford et al. struggles with this recent history. %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800048/