外周血有核细胞DNA损伤检测在肺多原发癌患者诊断中的临床价值
DOI: 10.3971/j.issn.1000-8578.2015.04.012
Keywords: A Meta-analysis,Effect of Rap2a on Invasion and Metastasis of Lung Cancer Cells and Its Related Mechanism,NSCLC的疫苗治疗研究进展,Immune Killing Effect of Silencing TIPE2 Expression on T Lymphocytes Against Lung Adenocarcinoma Cells LA795,Clinical Investigation on Qingfei Mixture Combined with Chemotherapy on Middle and Advanced Non-small Cell Lung Cancer,Effect of Vascular Endothelial Cadherin on Invasion and Metastasis of Non-small Cell Lung Cancer Cells and Related Mechanism,Advances of FGF/FGFR Signaling Pathway in Targeted Therapy for Squamous Cell Lung Cancer,Sulforaphane Suppressed Proliferation of Lung Cancer Stem Cells in vitro,Experiment of Different Administration Sequences of Apatinib and Paclitaxel on Lung Cancer,Cryptotanshinone Promotes Apoptosis of A549 Cells via Inhibiting Cap-dependent mRNA Translation,Expressions of MMP-7 mRNA, sMICA, VEGF in Peripheral Blood of Lung Cancer Patients and Their Relationships with Invasion and Metastasis,Quality Assessment of Reports of Randomized Controlled Trials Published in Chinese in Field of Non-small Cell Lung Cancer in China
Abstract:
摘要 目的 本研究旨在探讨外周血单个有核细胞DNA损伤在肺多原发癌和转移癌鉴别诊断中的临床应用价值。方法 应用微量全血单细胞凝胶电泳技术（彗星实验）分别检测28例转移癌、30例肺多原发癌和29例原发肺癌患者外周血单个有核细胞DNA损伤率及损伤程度。结果 转移癌组外周血单个有核细胞损伤阳性率为6.29%（176/2800），显著高于肺多原发癌组3.77%（113/3000），（χ2=18.883,P=0.000）；肺多原发癌组显著高于原发肺癌组2.66%（77/2900），（χ2=5.494, P=0.019）。转移癌组外周血单个有核细胞DNA损伤的尾长、尾矩和椭圆矩分别为（44.19±13.48）μm、（4.53±1.66）和（4.64±1.50） ，显著高于肺多原发癌组[（34.85±8.40）μm、（3.30±1.04）和（3.54±1.03） ]，（P=0.000）；肺多原发癌组显著高于原发肺癌组[（26.25±7.64）μm 、（2.20±0.98） 和（2.37±0.78）]，（P=0.000）。结论 检测外周血单个有核细胞DNA损伤有助于肺多原发癌与转移癌的鉴别诊断
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