%0 Journal Article
%T 外周血有核细胞DNA损伤检测在肺多原发癌患者诊断中的临床价值
%A 周渝斌
%A 杜恒
%A 沈诚
%A 车国卫
%A 陈大理
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.04.012
%X 摘要 目的 本研究旨在探讨外周血单个有核细胞DNA损伤在肺多原发癌和转移癌鉴别诊断中的临床应用价值。方法 应用微量全血单细胞凝胶电泳技术（彗星实验）分别检测28例转移癌、30例肺多原发癌和29例原发肺癌患者外周血单个有核细胞DNA损伤率及损伤程度。结果 转移癌组外周血单个有核细胞损伤阳性率为6.29%（176/2800），显著高于肺多原发癌组3.77%（113/3000），（χ2=18.883,P=0.000）；肺多原发癌组显著高于原发肺癌组2.66%（77/2900），（χ2=5.494, P=0.019）。转移癌组外周血单个有核细胞DNA损伤的尾长、尾矩和椭圆矩分别为（44.19±13.48）μm、（4.53±1.66）和（4.64±1.50） ，显著高于肺多原发癌组[（34.85±8.40）μm、（3.30±1.04）和（3.54±1.03） ]，（P=0.000）；肺多原发癌组显著高于原发肺癌组[（26.25±7.64）μm 、（2.20±0.98） 和（2.37±0.78）]，（P=0.000）。结论 检测外周血单个有核细胞DNA损伤有助于肺多原发癌与转移癌的鉴别诊断
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%U http://www.zlfzyj.com/CN/abstract/abstract8468.shtml