血清25-羟基维生素D3及钙水平与胃癌的关系
DOI: 10.3971/j.issn.1000-8578.2015.04.011
Keywords: 2 Matched Case-control Investigation on Risk Factors of Gastric Cancer in Xianyou County,Expression of CLIC4 in Gastric Carcinoma Tissues and Its Relevance to Microsatellite Instability,Efficacy and Safety of Weekly Liposome-paclitaxel or Oxaliplatin Combined with Tegafur on Elderly Advanced Gastric Cancer,Periplocin Extracted from Cortex Periplocae(CPP) Induced Apoptosis of Gastric Cancer Cells MGC-803 Through Lysosomal Pathway,Gastric Cancer Mortality Trend and Difference Decomposition Analysis in Kunshan, Jiangsu Province, 1981-2014,Effect of Ubiquitin-like with PHD and Ring Finger Domain 1 on Invasion and Metastasis of Gastric Cancer and Related Mechanism,Effects of miR-711 on Invasion, Metastasis and Epithelial Mesenchymal Transition of Gastric Cancer Cells MGC-803,Role of p53β Isoform in Inhibitory Effect of rmhTNF Combined with Cisplatin on Human Gastric Cancer Cell Growth,Effect of siRNA Targeting Migration-inducing Protein 7 Gene on Invasion and Migration of Human Gastric Cancer Cells MKN45,Optimization of Housekeeping Gene for Normalization of Quantitative Polymerase Chain Reaction Assay in Gastric Cancer Research,A Case Report of Synchronous Gastric Cancer and Gastric Diffuse Large B-Cell Lymphoma,Development of Peritoneal Carcinomatosis from Gastric Cancer and Current Status of Treatment in China
Abstract:
摘要 目的 探讨血清25-(OH)D3及钙（Ca2+）水平与胃癌的关系。方法 选取郑州大学第一附属医院经病理确诊为慢性浅表性胃炎（对照组）患者63例，胃癌（病例组）患者118例。采用酶联免疫吸附法（ELISA）测定入选对象血清25-(OH)D3水平，离子选择性电极（ISE）电位法测定入选对象血清Ca2+水平。结果 病例组外周血25-(OH)D3水平显著低于对照组（t=15.07，P=0.000），而其血清Ca水平与对照组比较，差异无统计学意义（t=1.109，P=0.269），病例组内血清25-(OH)D3水平与Ca2+之间呈正相关（r=0.706，P=0.000）。外周血25-(OH)D3水平在不同细胞分化程度的胃癌组间差异有统计学意义（F=3.356，P=0.038）。胃癌经手术治疗后，术后外周血25-(OH) D3水平高于术前，差异有统计学意义（t=？8.017，P=0.000）。但胃癌淋巴结转移与无淋巴结转移组间血清25-(OH)D3水平无统计学意义（t=0.061，P=0.952）。结论 血清 25-(OH)D3水平可能与胃癌的发生、发展相关，手术治疗后其水平明显升高，可用于监测胃癌患者病情变化、预测预后
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