%0 Journal Article
%T 血清25-羟基维生素D3及钙水平与胃癌的关系
%A 孙静
%A 曾亚菲
%A 褚燕君
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.04.011
%X 摘要 目的 探讨血清25-(OH)D3及钙（Ca2+）水平与胃癌的关系。方法 选取郑州大学第一附属医院经病理确诊为慢性浅表性胃炎（对照组）患者63例，胃癌（病例组）患者118例。采用酶联免疫吸附法（ELISA）测定入选对象血清25-(OH)D3水平，离子选择性电极（ISE）电位法测定入选对象血清Ca2+水平。结果 病例组外周血25-(OH)D3水平显著低于对照组（t=15.07，P=0.000），而其血清Ca水平与对照组比较，差异无统计学意义（t=1.109，P=0.269），病例组内血清25-(OH)D3水平与Ca2+之间呈正相关（r=0.706，P=0.000）。外周血25-(OH)D3水平在不同细胞分化程度的胃癌组间差异有统计学意义（F=3.356，P=0.038）。胃癌经手术治疗后，术后外周血25-(OH) D3水平高于术前，差异有统计学意义（t=？8.017，P=0.000）。但胃癌淋巴结转移与无淋巴结转移组间血清25-(OH)D3水平无统计学意义（t=0.061，P=0.952）。结论 血清 25-(OH)D3水平可能与胃癌的发生、发展相关，手术治疗后其水平明显升高，可用于监测胃癌患者病情变化、预测预后
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%U http://www.zlfzyj.com/CN/abstract/abstract8467.shtml