滑膜肉瘤相关发病机制的研究进展
DOI: 10.3971/j.issn.1000-8578.2015.07.016
Keywords: 滑膜肉瘤,发病机制,SYT-SSX,上皮-间质转化,Relationship Between Human Papillomavirus and miRNA Expression,Advances on Etiology of Uterine Leiomyosarcoma,Advances of Aberrant miRNAs Expression in Multiple Myeloma,Progress on Osteosarcoma Pathogenesis,Expression and Clinical Signifi cance of E-cadherin and N-cadherin in Nasopharyngeal#br# Carcinoma,Effect of Hypoxia and HIF-1α on Epithelial-mesenchymal Transition,Invasion and Proliferation in Colorectal Cancer,Clinicopathologic Features and Epidermal Growth Factor Receptor Mutations Associated with Epithelial-mesenchymal Transition in Non-small Cell Lung Cancer,The Mechanism of Prolactinomas Induced by Estrogen in Rats,A Study of the Mechanism and Treatment Strategics in Malignant Tumor Complicated by Deep Venous Thrombosis,PRJMARY MALIGNANT TUMORS INVOLVED THE CENTAL NERVOUS SYSTFM
Abstract:
摘要 滑膜肉瘤（synovial sarcoma, SS）是源于关节、滑膜及腱鞘滑膜的软组织恶性肿瘤，因其在关节周围的经典表现而得名。滑膜肉瘤可发生在身体任何部位，但以四肢近关节处多见。95%的SS以t（X;18）（p11.2-q11.2）染色体易位为特点，形成融合基因SYT-SSX，从而通过Wnt/β-catenin、PcG和ERK等信号通路促进SS细胞发生。另外，TGF-β1、Smad、Snail和Slug通过EMT途径也参与SS的发生发展。除此之外SS的发病还涉及有许多因子改变，如Twist1、Bmi1等。近年来研究表明上述因素均和SS的发病机制有关。本文将对这些因素在SS发生发展方面的作用作一概述
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